Don't you guys think that a sequel to Sonic Chronicles would be the perfect introduction of the Freedom Fighters in the games? I do.
Given that I remain rather stalwart in my opposition to the integration of the Freedom Fighters with the mainline Sega continuity, I'm going to have to go with a resounding no.
I would kill for an ME style Sonic RPG with the Satam cast.
While I love the Mass Effect games (or rather, the latter two as well as the last act of the first), they seem a rather poor fit for SatAM or Sonic in general. The combat mechanics ultimately revolve around shooting, an element that is clearly inconsistent with the aesthetics of the Freedom Fighters, as well as any inference that their refusal to use firearms is a deliberate one. The tech powers of Mass Effect would fit reasonably well enough, but alone could not carry the gameplay.
More pressing is the matter of player agency in regard to narrative. Rather than being a player avatar like Commander Shepard, the characters of SatAM already have their own preset personalities. Giving the player more than a very small window of choice in terms of dialogue would result in options that would simply be out of character for the protagonist, whether Sonic, Sally, or someone else. The alternative to accepting this narrow scope of narrative choice would be for the protagonist to be an original character, resulting in a story that comes across as little more than poor self-insert fanfiction.